Background: Resistance exercise increases muscle mass and function in older adults, but responses are attenuated compared with younger people. Data suggest that long-chain n—3 polyunsaturated fatty acids PUFAs may enhance adaptations to resistance exercise in older women. To our knowledge, this possibility has not been investigated in men. Objective: We sought to determine the effects of long-chain n—3 PUFA supplementation on resistance exercise training—induced increases in muscle mass and function and whether these effects differ between older men and women. Muscle size, strength, and quality strength per unit muscle area , functional abilities, and circulating metabolic and inflammatory markers were measured before and after the intervention. Conclusion: Long-chain n—3 PUFA supplementation augments increases in muscle function and quality in older women but not in older men after resistance exercise training. This trial was registered at clinicaltrials.
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